Endocrine Abstracts

Introduction: Radioiodine ablation with a whole-body scan is a well known therapeutic regimen for differentiated thyroid cancer. I-131 uptake in the breast has been described with a variety of normal and pathologic conditions such as gynecomastia, supernumerary breasts, fibroadenoma and lactational duct cyst or galactocele. Here we report a case with an incidental radioiodine uptake in breast who turned out to be breast cancer.Case report: A 70 years old...

Proton pump inhibitor (PPI) drugs which are used safely to treat peptic ulcus disease since 2 decades, moderately increases gastrin hormone by decreasing gastric acid secretion. Preclinical studies show that gastrin itself, or drugs that increase gastrin levels such as PPIs, increase islet cell mass and improve glycaemic control. To the best of our knowledge one prospective and some retrospective studies claim that PPI medication in diabetic patients leads to an average decrea...

Experimental and clinical studies suggest that blocking the effects of angiotensin II increases insulin sensitivity, skeletal muscle glucose transport, and pancreatic blood flow which may contribute to the prevention of diabetes mellitus. Although large scale studies and meta-analysis reveal that the new onset of diabetes could be significantly decreased by ARBs in both hypertensive and normotensive patients, their effect on glucose regulation in patients already diagnosed wit...

Large scale clinical studies and meta-analysis suggest that treatment with angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) could have protective effect against diabetes development. While diuretics and β-blockers have some well known adverse effect on glycaemic regulation, ARBs/ACEIs’ effect on glucose regulation in patients already diagnosed with diabetes has not been investigated well enough. Also to the best of our knowled...

The prevalance of incidentally discovered adrenal masses increased in last three decades. The major clinical concern is the risk of malignancy and hormone overproduction but most of them are non-fonctional and benign. Current practices in the management of adrenal incidentalomas reevaluated the follow-up suggestions considering low probability of the transformation of a benign and non-functional adrenal mass to a malignant or functional one. Therefore, in the present study we ...

While statins which are used safely to treat dyslipidemia, and improve cardiovascular mortality, recent articles claim that they also impairs glycaemic control in type 2 diabetes patients. Meta-analysis of larger scale studies indicate that use of statins is associated with an increase of 9% in diabetes onset. Despite that, we know not much about their effect on glucose regulation in patients already diagnosed with diabetes. Therefore, we aimed to investigate the effect of sta...

Introduction: There is accumulating evidence on the favourable effects of some statins on bone and mineral metabolism. Although some studies have reported drop of serum 25-hydroxyvitamin D levels in subjects receiving statin therapy, comparative studies evaluating various statins in prospective randomized design is lacking. Our purpose is to compare the effects of variable doses of rosuvastatin and atorvastatin on serum 25-hydoxyvitamin D levels adjusted for seasons.<p cla...

Diabetic foot is one of the most feared complication of diabetes. The tendons and ligaments’ stiffness and elasticity are known to be altered in diabetic foot. Achilles tendon (AT) plays an important for foot biomechanics and the altered stiffness of AT may have a role in pathogenesis of diabetic foot. Determination of the early changes in AT may help to identify the risky patients for diabetic foot. Acoustic Radiation Force Impulse (ARFI) Elastography is an elastography ...

IntroductionThere are very limited number of clinical studies and data on the effect of thyroid dysfunction in hypothyroidism on connective tissue. Tendinitis can be the first complaint in hypothyroidism and symptomatic relief can be provided with the appropriate treatment of primary thyroid deficiency. There are studies, showed softening in Achilles tendon with age, in patients with intermittent claudication, diabetes patients, and chronic kidney failur...

IntroductionThyroid cancers account for about 2.9%of all cancers. Although it is reported that the risk of developing PTC as the second primary cancer increases after treatment of Hodgkin lymphoma (HL), concomitant PTC and HL are quite rare and to the best of our knowledge we found only three cases in the literature. This case report presents the treatment management and three-year course of a male patient with simultaneous diagnosis of PTC and HL.<p...